SPOTLIGHTNew Senolytic Vaccine Extends Lifespan and Rejuvenates Immune Cells in Mice, Study Finds
A nanovaccine that helps the immune system clear senescent fat cells improves metabolic health and moderately extends the lifespan of naturally aged and obese mice.
Seragon Reports Record-Breaking Data on SRN-901, a New Drug That Extends Mouse Lifespan by 33%
In a late-life mouse study, the multi-component drug candidate increased remaining lifespan by 33%, slowed frailty progression, and reduced tumor incidence, according to data published in Drug Design, Development and Therapy.
Buck Institute Study: Ketone Supplement Curbs Age-Related Autoimmunity
Without impairing immune responses, ketone esters reduce activation of a type of white blood cell (age-related B cells) that contribute to autoimmunity in aged mice.
Arnold Schwarzenegger Weighs in on Strength Training and Cardio for Longevity
Bodybuilding legend Arnold Schwarzenegger relays how individuals who regularly perform both strength training and cardio exercise experience the greatest longevity benefits.
Popular Antioxidant Supplement May Worsen Muscle Wasting in Aging, New Study Suggests
Millions take antioxidants for longevity, but Danish scientists have found that blocking oxidants with N-acetylcysteine (NAC) may actually accelerate muscle wasting in mice.
Senolytic Drugs Improve Memory and Reduce Brain Cholesterol During Aging
Senolytic drugs dasatinib and quercetin improved memory in mice with accelerated aging while reducing cholesterol buildup and inflammation in the brain.
Plant Compound Restores Muscle Strength During Aging by Reactivating Muscle Stem Cells
Plant compound diosgenin improves muscle strength and endurance in aged mice by reactivating muscle stem cells and restoring SIRT1 signaling.
What Technologies Are Closest to Achieving Age Reversal?
Several approaches target the biology of aging, from cellular reprogramming to inflammation control, but early findings have yet to establish whole-body rejuvenation in humans.
NMN-Producing Probiotics May Outperform NMN Itself in Combating Age-Related Decline, Suggest New Study
While NMN (nicotinamide mononucleotide) increased lifespan by 3.5%, NMN-producing gut bacteria from humans increased lifespan by 11.2% and enhanced sensory perception more than NMN in nematodes that model dementia.
Harvard’s David Sinclair Explores the Science and the Hype Behind Peptides
Harvard’s David Sinclair reviews the peptides GHK-Cu, epitalon, and apelin against the hallmarks of aging, and cautions that most of the data come from cells and animals.
- Aging & Longevity
Seragon Reports Record-Breaking Data on SRN-901, a New Drug That Extends Mouse Lifespan by 33%
In a late-life mouse study, the multi-component drug candidate increased remaining lifespan by 33%, slowed frailty progression, and reduced tumor incidence, according to data published in Drug Design, Development and Therapy.
- Immunity
Buck Institute Study: Ketone Supplement Curbs Age-Related Autoimmunity
Without impairing immune responses, ketone esters reduce activation of a type of white blood cell (age-related B cells) that contribute to autoimmunity in aged mice.
- Aging & Longevity
Arnold Schwarzenegger Weighs in on Strength Training and Cardio for Longevity
Bodybuilding legend Arnold Schwarzenegger relays how individuals who regularly perform both strength training and cardio exercise experience the greatest longevity benefits.
- Bone, Muscle & Skin
Popular Antioxidant Supplement May Worsen Muscle Wasting in Aging, New Study Suggests
Millions take antioxidants for longevity, but Danish scientists have found that blocking oxidants with N-acetylcysteine (NAC) may actually accelerate muscle wasting in mice.
- Neurological
Senolytic Drugs Improve Memory and Reduce Brain Cholesterol During Aging
Senolytic drugs dasatinib and quercetin improved memory in mice with accelerated aging while reducing cholesterol buildup and inflammation in the brain.
- Bone, Muscle & Skin
Plant Compound Restores Muscle Strength During Aging by Reactivating Muscle Stem Cells
Plant compound diosgenin improves muscle strength and endurance in aged mice by reactivating muscle stem cells and restoring SIRT1 signaling.
- Aging & Longevity
What Technologies Are Closest to Achieving Age Reversal?
Several approaches target the biology of aging, from cellular reprogramming to inflammation control, but early findings have yet to establish whole-body rejuvenation in humans.
- Neurological
NMN-Producing Probiotics May Outperform NMN Itself in Combating Age-Related Decline, Suggest New Study
While NMN (nicotinamide mononucleotide) increased lifespan by 3.5%, NMN-producing gut bacteria from humans increased lifespan by 11.2% and enhanced sensory perception more than NMN in nematodes that model dementia.
- Aging & Longevity
Harvard’s David Sinclair Explores the Science and the Hype Behind Peptides
Harvard’s David Sinclair reviews the peptides GHK-Cu, epitalon, and apelin against the hallmarks of aging, and cautions that most of the data come from cells and animals.
STUDIES
NEWS
Buck Institute Study: Ketone Supplement Curbs Age-Related Autoimmunity
Without impairing immune responses, ketone esters reduce activation of a type of white blood cell (age-related B cells) that contribute to autoimmunity in aged mice.
New Senolytic Vaccine Extends Lifespan and Rejuvenates Immune Cells in Mice, Study Finds
A nanovaccine that helps the immune system clear senescent fat cells improves metabolic health and moderately extends the lifespan of naturally aged and obese mice.
Arnold Schwarzenegger Weighs in on Strength Training and Cardio for Longevity
Bodybuilding legend Arnold Schwarzenegger relays how individuals who regularly perform both strength training and cardio exercise experience the greatest longevity benefits.
Popular Antioxidant Supplement May Worsen Muscle Wasting in Aging, New Study Suggests
Millions take antioxidants for longevity, but Danish scientists have found that blocking oxidants with N-acetylcysteine (NAC) may actually accelerate muscle wasting in mice.
Senolytic Drugs Improve Memory and Reduce Brain Cholesterol During Aging
Senolytic drugs dasatinib and quercetin improved memory in mice with accelerated aging while reducing cholesterol buildup and inflammation in the brain.
Plant Compound Restores Muscle Strength During Aging by Reactivating Muscle Stem Cells
Plant compound diosgenin improves muscle strength and endurance in aged mice by reactivating muscle stem cells and restoring SIRT1 signaling.
What Technologies Are Closest to Achieving Age Reversal?
Several approaches target the biology of aging, from cellular reprogramming to inflammation control, but early findings have yet to establish whole-body rejuvenation in humans.
NMN-Producing Probiotics May Outperform NMN Itself in Combating Age-Related Decline, Suggest New Study
While NMN (nicotinamide mononucleotide) increased lifespan by 3.5%, NMN-producing gut bacteria from humans increased lifespan by 11.2% and enhanced sensory perception more than NMN in nematodes that model dementia.
Harvard’s David Sinclair Explores the Science and the Hype Behind Peptides
Harvard’s David Sinclair reviews the peptides GHK-Cu, epitalon, and apelin against the hallmarks of aging, and cautions that most of the data come from cells and animals.
The Aging Brain May Be Adapting, Not Just Declining—Here’s What That Could Mean for Brain Health
Researchers propose that aging shifts the brain toward accumulated knowledge and big-picture thinking, suggesting that cognitive longevity may involve nurturing these strengths.
Blue Zones and Extreme Longevity: Why We Need Better Evidence
Researchers argue that claims of extreme-longevity geographical hotspots require transparent data, validated ages, and standardized identification methods before they can reliably inform healthy-aging research.
Urolithin A Counters Memory Loss from Sleep Deprivation in Aged Mice, New Study Shows
NMN Counters Brain and Muscle Aging by Targeting Blood Vessels, New Study Shows
NMN (nicotinamide mononucleotide) improves the survival, memory, and endurance of mice with low blood vessel NAD+ (nicotinamide adenine dinucleotide) levels.
Can Boosting NAD+ Protect the Aging Brain?
Researchers are investigating whether restoring declining NAD+ levels can support brain metabolism and resilience with age, but compelling human evidence is still emerging.
Longevity Supplement Spermidine Rejuvenates Stem Cells Killed by Chronic Stress, New Study Shows
Supplementing mice with the naturally occurring molecule spermidine counters stem cell death and alterations to immune cells triggered by chronic stress.